Effect of Aloe Vera Leaf Extract on Alloxan Induced Diabetes in Young Mice

Diabetes mellitus is a group of metabolic disorders, characterized by defects in insulin secretion, insulin action or both. The synthetic oral drugs are used for treatment of diabetes. These drugs are associated with number of side effects. Management of diabetes withought any side effect is still challenge to medical system. Present work aimed to evaluate hypoglycemic and antioxidant potency of Aloe vera leaf extract in alloxan induced diabetis in young mice. For this work young mice (1-2 month) divided into three groups viz; control group, alloxan induced diabetic group and recovery group were used. The estimation of blood glucose level and antioxidative enzymes viz; Superoxide dismutase (SOD), Catalase (CAT) and Glutathione peroxidase (GPx) was carried out from pancreas. The treatment of Aloe vera leaf extract resulted in to a remarkable decrease in blood glucose level and an increase in SOD, CAT, and GPx in the pancreas of diabetic mice.